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Compared with patients with minimal (1%) overlap of paroxetine with tamoxifen, use of paroxetine for 41% of tamoxifen treatment (the median overlap in our sample 8% to 80%) would result in one additional breast cancer death at five years for every 19.

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More importantly, the combined treatment of ERAP and tamoxifen additively inhibited the expression of ERα target genes () and the development of KPL-3C xenografts as compared with tamoxifen or ERAP alone ().

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